The extended structure of the remote cluster B514 in M31. Detection of extra-tidal stars

We present a study of the density profile of the remote M31 globular cluster B514, obtained from HST/ACS observations. Coupling the analysis of the distribution of the integrated light with star counts we can reliably follow the profile of the cluster out to r~35", corresponding to ~130pc. The profile is well fitted, out to ~15 core radii, by a King Model having C=1.65. With an estimated core radius r_c=0.38", this corresponds to a tidal radius of r_t~17" (~65pc). We find that both the light and the star counts profiles show a departure from the best fit King model for r>~8" - as a surface brightness excess at large radii, and the star counts profile shows a clear break in correspondence of the estimated tidal radius. Both features are interpreted as the signature of the presence of extratidal stars around the cluster. We also show that B514 has a half-light radius significantly larger than ordinary globular clusters of the same luminosity. In the M_V vs. log r_h plane, B514 lies in a region inhabited by peculiar clusters, like Omega Cen, G1, NGC2419 and others, as well as by the nuclei of dwarf elliptical galaxies.Comment: 9 pages, 6 figures. Accepted for publication in Astronomy & Astrophysic

Disinvestment in healthcare: An overview of HTA agencies and organizations activities at European level

Background: In an era of a growing economic pressure for all health systems, the interest for "disinvestment" in healthcare increased. In this context, evidence based approaches such as Health Technology Assessment (HTA) are needed both to invest and to disinvest in health technologies. In order to investigate the extent of application of HTA in this field, methodological projects/frameworks, case studies, dissemination initiatives on disinvestment released by HTA agencies and organizations located in Europe were searched. Methods: In July 2015, the websites of HTA agencies and organizations belonging to the European network for HTA (EUnetHTA) and the International Network of Agencies for HTA (INAHTA) were accessed and searched through the use of the term "disinvestment". Retrieved deliverables were considered eligible if they reported methodological projects/frameworks, case studies and dissemination initiatives focused on disinvestment in healthcare. Results: 62 HTA agencies/organizations were accessed and eight methodological projects/frameworks, one case study and one dissemination initiative were found starting from 2007. With respect to methodological projects/frameworks, two were delivered in Austria, one in Italy, two in Spain and three in U.K. As for the case study and the dissemination initiative, both came from U.K. The majority of deliverables were aimed at making an overview of existing disinvestment approaches and at identifying challenges in their introduction. Conclusions: Today, in a healthcare context characterized by resource scarcity and increasing service demand, "disinvestment" from low-value services and reinvestment in high-value ones is a key strategy that may be supported by HTA. The lack of evaluation of technologies in use, in particular at the end of their lifecycle, may be due to the scant availability of frameworks and guidelines for identification and assessment of obsolete technologies that was shown by our work. Although several projects were carried out in different countries, most remain constrained to the field of research. Disinvestment is a relatively new concept in HTA that could pose challenges also from a methodological point of view. To tackle these challenges, it is necessary to construct experiences at international level with the aim to develop new methodological approaches to produce and grow evidence on disinvestment policies and practices

Correlations of Globular Cluster Properties: Their Interpretations and Uses

Correlations among the independently measured physical properties of globular clusters (GCs) can provide powerful tests for theoretical models and new insights into their dynamics, formation, and evolution. We review briefly some of the previous work, and present preliminary results from a comparative study of GC correlations in the Local Group galaxies. The results so far indicate that these diverse GC systems follow the same fundamental correlations, suggesting a commonality of formative and evolutionary processes which produce them.Comment: An invited review, to appear in "New Horizons in Globular Cluster Astronomy", eds. G. Piotto, G. Meylan, S.G. Djorgovski, and M. Riello, ASPCS, in press (2003). Latex file, 8 pages, 5 eps figures, style files include

Treatment of esophageal achalasia in children: Today and tomorrow

Esophageal achalasia (EA) is a rare esophageal motility disorder in children. Laparoscopic Heller myotomy (LHM) represents the treatment of choice in young patients. Peroral endoscopic myotomy (POEM) is becoming an alternative to LHM. The aim of this study is to evaluate the effectiveness, safety, and outcomes of POEM vs LHM in treatment of children with EA. Data of pediatric patients with EA, who underwent LHM and POEM from February 2009 to December 2013 in two centers, were collected. Eighteen patients (9 male, mean age: 11.6 years; range: 2-17 years) were included. Nine patients (6 male, mean age: 10.7 years; range: 2-16 years) underwent LHM, and the other 9 (3 males, mean age: 12.2 years; range: 6-17 years) underwent POEM procedure. Mean operation time was shorter in POEM group compared with LHM group (62/149 minutes). Myotomy was longer in POEM group than in LHM group (11/7 cm). One major complication occurred after LHM (esophageal perforation). No clinical and manometric differences were observed between LHM and POEM in follow-up. The incidence of iatrogenic gastroesophageal reflux disease was low (1 patient in both groups). Results of a midterm follow-up show that LHM and POEM are safe and effective treatments also in children. Besides, POEM is a mini-invasive technique with an inferior execution timing compared to LHM. A skilled endoscopic team is mandatory to perform this procedur

Variable stars and stellar populations in Andromeda XXI: II. Another merged galaxy satellite of M31?

B and V time-series photometry of the M31 dwarf spheroidal satellite Andromeda XXI (And XXI) was obtained with the Large Binocular Cameras at the Large Binocular Telescope. We have identified 50 variables in And XXI, of which 41 are RR Lyrae stars (37 fundamental-mode RRab, and 4 first-overtone RRc, pulsators) and 9 are Anomalous Cepheids (ACs). The average period of the RRab stars ( = 0.64 days) and the period-amplitude diagram place And~XXI in the class of Oosterhoff II - Oosterhoff-Intermediate objects. From the average luminosity of the RR Lyrae stars we derived the galaxy distance modulus of (m-M)$_0$=$24.40\pm0.17$ mag, which is smaller than previous literature estimates, although still consistent with them within 1 $\sigma$. The galaxy color-magnitude diagram shows evidence for the presence of three different stellar generations in And~XXI: 1) an old ($\sim$ 12 Gyr) and metal poor ([Fe/H]=$-$1.7 dex) component traced by the RR Lyrae stars; 2) a slightly younger (10-6 Gyr) and more metal rich ([Fe/H]=$-$1.5 dex) component populating the red horizontal branch, and 3) a young age ($\sim$ 1 Gyr) component with same metallicity, that produced the ACs. Finally, we provide hints that And~XXI could be the result of a minor merging event between two dwarf galaxies.Comment: accepted for publications in Ap

The Kinematics and Metallicity of the M31 Globular Cluster System

With the ultimate aim of distinguishing between various models describing the formation of galaxy halos (e.g. radial or multi-phase collapse, random mergers), we have completed a spectroscopic study of the globular cluster system of M31. We present the results of deep, intermediate-resolution, fibre-optic spectroscopy of several hundred of the M31 globular clusters using the Wide Field Fibre Optic Spectrograph (WYFFOS) at the William Herschel Telescope in La Palma, Canary Islands. These observations have yielded precise radial velocities (+/-12 km/s) and metallicities (+/-0.26 dex) for over 200 members of the M31 globular cluster population out to a radius of 1.5 degrees from the galaxy center. Many of these clusters have no previous published radial velocity or [Fe/H] estimates, and the remainder typically represent significant improvements over earlier determinations. We present analyses of the spatial, kinematic and metal abundance properties of the M31 globular clusters. We find that the abundance distribution of the cluster system is consistent with a bimodal distribution with peaks at [Fe/H] = -1.4 and -0.5. The metal-rich clusters demonstrate a centrally concentrated spatial distribution with a high rotation amplitude, although this population does not appear significantly flattened and is consistent with a bulge population. The metal-poor clusters tend to be less spatially concentrated and are also found to have a strong rotation signature.Comment: 33 pages, 20 figure